In my workshop yesterday someone brought the new Sekonic loaded with the profile for the 5D and it was off.
Best thing is to make your own profile.
Buy the cheap QPCARDS, they are perfect for this.
Place the card lit by a BROAD lightsource and measure your card.
Now take the shot.
Use a RAW convertor that is camera native, Mamiya DS, DPP, Capture One etc.
It HAS to have a histogram viewer with a MIDPOINT and it HAS to be totally neutral, don't trust lightroom or ACR because they show you an underexposed histogram while it's not.
Now crop the white and gray patch and do a whitebalance on the gray patch.
if you are measuring correct the gray patch should be dead center and the whites should not overexpose.
If the gray is not deadcenter adjust your meter for compensation.
A few pointers.
Use a GOOD flash system, forget it with falcon eyes, Jinbei or whatever chinese brand, when you measure six pops you will get six different outcomes. I use Elinchrom and I know profoto and those two brands are 100% accurate every pop.
But you can check this of course yourself.
Remember that you have to this for EVERY ISO and EVERY BODY and sometimes even every lens although with lenses the difference is often very very minor, but especially some cheaper brands and step in lenses will differ.
Is it a lot of work ?
Actually not.
In the studio you often use one body, and one ISO setting.
On location I always trust my camera meter unless I use mix lights when I'm (you guessed it) back on the same ISO I use in the studio.
I will have a chapter on this on the new instructional DVD by the way