I ran the ACR calibration this week for both of my cameras, 5D and Aptus 22. The Aptus has had much nicer color in LR than any of the Canons I've owned. But running the calibration made even better improvements, notably in the skin, it pulled some extra red/magenta out of skin that I just couldn't pinpoint with settings otherwise.
Here is an updated calibration script, easy, it takes ~30 mins to run in PS on a G5.
http://21stcenturyshoebox.com/tools/ACRcalibrator.htmlFor what settings I use in LR, it just depends on the images. I have found I can make some presets with treatments as starting points, but they just won't work with all shots, some require more adjustments due to contrast and scene specific content.
For WB in LR, I use the as shot setting or manually adjust. The drop down menu of WB settings are pointless, because every camera will have different needs for what is neutral to start with. A grey card isn't always an option.
My Aptus needs around a -25 to -30 tint setting and a lower WB than Canon for neutral.
I go with little to no noise reduction on the Aptus, starting point of Lum noise 0 and Color noise 5. Even at ISO 200 the Aptus looks great with just a slight fine grain which never shows in print. Pushing files to ISO 400-800 looks nice in B&W with an acceptable grainy look.
Split toning rocks. I use it regularly for lightly toned B&Ws to have nearly finished files straight from LR.

It's also useful for intentionally off toned color images like this, Eastman Chemical shoot:

Leaf Capture has the best pixel detail for Leaf files but lacks so much for what I want to do with files that LR is my choice with little if any PS work afterwards.