QUOTE (The View @ Oct 14 2008, 08:16 AM)

Another possibility would be directory trouble.
Do you have access to DiscWarrior? It's a software maintenance tool for the Mac, costs about 100$, and generally a good thing to have.
It would be interesting to know if the problem comes from Bridge. Did you try to open the files through the finder? What happens then?
You also said LARGE file. Small files open well? How small? Do you have an idea from which file size on the freeze/crash will happen?
I do have DiscWarrior and apart from a few mis-named files that it shows on the computer all seems fine, at least according to DW.
I haven't tried opening the files through Bridge yet, must try that.
Small files are typically around 30mb, larger files over 1gb. Problems start happening with files around 300mb in size.
QUOTE (francois @ Oct 14 2008, 09:41 AM)

So, it means that your problem is system-wide. Any error messages in the Console (/Applications/Utilities/Console.app)? Does it happen with a specific large file or with any large file? System crashes and kernel panics are very often caused by bad RAM or hardware issues.
What happens if you start up your Mac in Safe Mode (press the shift key during the start-up). I understand that you have checked your hard disk (and not only disk permissions) with Disk Utility application.
It happens with any file from around 300mb in size. I tried opening a file over 1gb in size a few days ago and it froze the computer for quite some time. I haven't tried starting up in Safe Mode, will try that as well.
Thanks for the responses on this. Not at my main computer, where the problems are happening, right now but will check this afternoon.